We have an opportunity for people with Parkinson’s to take part in some research looking at treatments for depressive symptoms in Parkinson’s.

ADepT-PD: A trial of treatments for depressive symptoms in Parkinson’s and to examine the effectiveness for delaying motor progression.Professor Anette Schrag and research teams across the UK are investigating what antidepressants may be the most beneficial for people with Parkinson’s that experience symptoms of depression. One of these antidepressants has also been suggested to reduce Parkinson’s progression.

The aim of the research is to examine the effectiveness of nortriptyline and escitalopram on symptoms of low mood or loss of enjoyment in people with Parkinson’s. They also want to understand if nortriptyline can slow down the progression of movement problems.
Who do the researchers need?
408 people diagnosed with Parkinson’s aged between 18-85 years. You must be experiencing feelings of low mood or enjoyment loss on most days and not currently be taking any antidepressants. 

What’s involved?
The treatment you will receive will be posted to your home. There will be five visits over a year either at your nearest research centre or remotely using video-calls. You will complete a number of questionnaires and have your movements assessed during each of these visits. The researchers may also invite you to take part in extra parts of the research looking at genetics, blood samples and movement monitoring.

For more information, please read the full Participant Information Sheet.

You will be reimbursed £10 for travel per visit.

Interested in taking part?
Please find your nearest centre by going to our Take Part Hub before December 2022.

If you have any other general questions, please email neuro.adept@ucl.ac.ukGo to the Take Part HubThis opportunity is not managed by Parkinson’s UK. 

Best Wishes, 

Amelia Hursey 
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